The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified.However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci.In this second study nested in the SCOURGE consortium, we conducted a genome-wide as
The structure and function of the sarcomere of striated muscle is well studied but the steps of sarcomere assembly and maintenance remain under-characterized.With the aid of chaperones and factors of the protein quality control system, muscle proteins can be folded and assembled into the contractile apparatus of the sarcomere.When sarcomere assembl
The absence of a globally-consistent and binding commitment to reducing greenhouse shamrock belt buckle emissions provides a rationale for partial policies, such as renewable energy mandates, product emission standards, etc to target lifecycle emissions of the regulated products or services.While appealing in principle, regulation of lifecycle emis
The disclosure of security vulnerabilities plays an important role in notifying vendors and the public about flaws in digital systems.Among the proposed disclosure approaches, the most utilized is Responsible Disclosure, which still suffers from fr5945 several disadvantages such as fostering a false sense of security among the end-users, allowing a